The US Preventive Services Task Force (USPSTF) recommends use of low- to moderate-dose statins for primary prevention in adults aged 40 to 75 years who have 1 or more CVD risk factors (dyslipidemia, diabetes, hypertension, or smoking) and a calculated 10-year CVD event risk of 10% or greater (B recommendation).

The USPSTF also recommends that clinicians selectively offer low- to moderate-dose statins to adults aged 40 to 75 years without a history of CVD who have 1 or more CVD risk factors and a calculated 10-year CVD event risk of 7.5% to 10% (C recommendation). The USPSTF concluded that there is insufficient to make a conclusion as to whether physicians should initiate statin use in adults 76 years and older.

Source: Statin Use for Primary Prevention of Cardiovascular Disease in Adults